Booth's boss, FBI Deputy Director Cullen, awaits news from doctors about his daughter, Amy, who has been diagnosed with a rare and deadly lug cancer. When Brennan hears about Amy, she finds it hard to believe a girl Amy's age has contracted the disease. Research reveals that Amy had a bone graft, leading Booth and Brennan to find the origin of the bone graft which helps to prove that Amy is the victim of a crime.