Brandon is 22-year old male, who ends up passing out after having rowdy sex with his fiancè. He complains of abdominal pain, nausea and suffers from fever and low blood pressure. House and Foreman test out their theories however after a dangerous drop in white blood cells they must find a solution and soon. After Wilson keeps nagging House about his nasty pill habit it proves extremely useful to House about Brandon's situation. Meanwhile in the clinic, House must deal with a boy and an unusual situation involving an MP3 player.