After two newborns in Princeton Plainsboro's maternity ward fall ill, House takes on the case. Soon the illness has spread to six babies, all of which have high fevers and low blood pressure which could mean that these newborns will die in less than a day. House wants to test which medicine works better, by putting one of the babies on a different medicine, despite the fact that this experiment may have a fatal effect, which angers Dr. Cameron and the rest of the specialists.