A young man comes into the hospital severely burned, but the test quickly show that their is something unusual about his blood tests. The team has to get creative to figure out how to test the patient before his body completely shuts down. To make matters worse, House is hellbent on proving that one of his old medical school colleague's new migraine drug does not work no matter what he happens to be saying. So, House decides to make himself the guinea pig for his own batch of tests with some painful results.