Just as House and his team are working on the a man with a giant, swollen tongue, a disgruntled former patient Jack Moriarty walks into House's office and shoots him. House decides he must continue to treat Vince from his ICU hospital bed with Moriarty, shot by hospital security and hand-cuffed to his bed, as his roommate. Soon, the aftereffects of the shooting begin to impact House and he starts to question his own ability to properly diagnose. As Vince's body deteriorates, House must struggle through his self-doubt and trust his team to find a way to solve the case.